May improve ovarian reserve and IVF response in poor responders
DHEA is a hormonal precursor that the ovaries convert into testosterone and estrogen. Research — primarily from reproductive medicine clinics — suggests that DHEA supplementation can improve ovarian reserve markers (AMH, antral follicle count), improve egg quality in women with diminished ovarian reserve, and increase IVF success rates in poor responders. The evidence is most compelling for women with low AMH or poor previous IVF response.
Women with low AMH (diminished ovarian reserve), poor previous IVF response, or premature ovarian insufficiency. Not recommended for women with normal or high ovarian reserve.
25–75 mg micronized DHEA daily. Most fertility clinics use 75 mg daily for 3–6 months before IVF.
Studies typically use 3–6 months of pretreatment before IVF cycles.
Acne, oily skin, facial hair growth (androgenic effects). May worsen PCOS — use with caution.
DO NOT use without consulting a fertility specialist. DHEA is a hormone precursor and can cause significant hormonal imbalances if used inappropriately. Not suitable for women with PCOS (already have elevated androgens).
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