Magnesium Glycinate

Some small trials have found that magnesium supplements may reduce period pain or PMS symptoms compared with placebo, but studies are small and of mixed quality, and reviews describe the evidence as limited. Severe or worsening period pain should be evaluated by a clinician, since it can be caused by conditions such as endometriosis.

People with period pain or PMS who want to discuss options with a clinician. Whether it suits you depends on your health, medicines and test results — ask a clinician.

Studies have used a range of doses, commonly 200–400 mg per day. The NIH upper limit for magnesium from supplements is 350 mg per day for adults. Doses vary by product and person; this is not personal medical advice.

Studies measured effects over 2–3 menstrual cycles. Some people notice no change.

Diarrhea, nausea and cramping. People with kidney disease should not take magnesium supplements without medical advice.

Reduce or stop if you get loose stools. See a clinician for severe pain, heavy bleeding or pain that is getting worse.

Evidence level (our editorial summary, not a formal grading): Limited to moderate.

Pregnancy & breastfeeding: Ask your provider before taking magnesium supplements in pregnancy.

Medication interactions: Can reduce absorption of some antibiotics, bisphosphonates and levothyroxine; can interact with diuretics.

Talk to a healthcare professional before use if you are pregnant, breastfeeding, planning pregnancy, have a medical condition, take any medicine, or are scheduled for surgery. Dietary supplements are not approved by the FDA for safety or effectiveness before they are sold, and quality varies between products.

Reliable sources to check: NIH Office of Dietary Supplements fact sheets · NCCIH Herbs at a Glance · MedlinePlus Herbs & Supplements · FDA — Dietary Supplements