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#1 Stress Adaptogen

Ashwagandha (KSM-66)

An herbal supplement studied for stress โ€” evidence is limited and short-term

๐Ÿ’† Stress

By the Bloom Health Woman editorial team ยท Last updated October 2026 ยท Educational information, not medical advice. This page contains an affiliate link (see the product box). How we create content

๐Ÿ’ก What the Research Says

Ashwagandha (Withania somnifera) is an herbal root extract that has been studied for stress and anxiety. A small 2012 placebo-controlled trial in adults using a branded root extract reported lower perceived-stress scores and lower blood cortisol after 60 days. Other trials are generally small and short, results vary by product, and long-term safety is not well established. Stress can affect the menstrual cycle in some people, but there is no good evidence that ashwagandha improves fertility or cycle regularity.

๐Ÿ‘ฉ Who It Is Commonly Discussed For

People interested in stress management. Not a replacement for care if you have anxiety, depression, burnout or thyroid disease. Whether it suits you depends on your health, medicines and test results โ€” ask a clinician.

โš—๏ธ Doses Used in Studies / Typical Label Amounts

Studies have used roughly 300โ€“600 mg of root extract daily, usually for 8โ€“12 weeks. Products vary widely. This is not a recommendation. Doses vary by product and person; this is not personal medical advice.

โฑ๏ธ Timeframes Reported

Trials typically measured effects after about 8โ€“12 weeks. Many people notice no change.

โš ๏ธ Possible Side Effects

Stomach upset, drowsiness and headache have been reported. Rare cases of liver injury have been reported โ€” stop and seek care for yellow skin/eyes, dark urine or severe stomach pain.

๐Ÿšจ Important Warnings

Avoid during pregnancy. Talk to a clinician first if you take thyroid medicines or have a thyroid condition (ashwagandha may affect thyroid hormone levels). Many clinicians advise stopping about 2 weeks before surgery.

๐Ÿ›ก๏ธ Safety Snapshot

Evidence level (our editorial summary, not a formal grading): Limited to moderate.

Pregnancy & breastfeeding: Avoid during pregnancy and breastfeeding unless a clinician advises otherwise.

Medication interactions: May interact with thyroid medicines, sedatives, immunosuppressants, and diabetes or blood-pressure medicines.

Talk to a healthcare professional before use if you are pregnant, breastfeeding, planning pregnancy, have a medical condition, take any medicine, or are scheduled for surgery. Dietary supplements are not approved by the FDA for safety or effectiveness before they are sold, and quality varies between products.

Reliable sources to check: NIH Office of Dietary Supplements fact sheets ยท NCCIH Herbs at a Glance ยท MedlinePlus Herbs & Supplements ยท FDA โ€” Dietary Supplements

๐Ÿ“‹ Medical Disclaimer: This information is for educational purposes only and is not medical advice. Always consult your doctor or pharmacist before starting any supplement, especially if you are pregnant, breastfeeding, have a medical condition, or take medications. See our Medical Disclaimer.

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Ashwagandha (KSM-66)

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๐Ÿ“Š Quick Facts
๐Ÿท๏ธ Category: ๐Ÿ’† Stress
โœ… Evidence (our summary): Limited to moderate