Folic acid can help reduce the risk of neural tube defects
🤰 PregnancyBy the Bloom Health Woman editorial team · Last updated October 2026 · Educational information, not medical advice. This page contains an affiliate link (see the product box). How we create content
Folic acid is the synthetic form of folate, a B vitamin needed for early development of the baby's brain and spine. The CDC advises that everyone who could become pregnant take 400 mcg of folic acid daily, because the neural tube forms very early — often before pregnancy is known — and folic acid can reduce the risk of neural tube defects such as spina bifida.
Anyone who could become pregnant, as advised by the CDC and other health authorities. Whether it suits you depends on your health, medicines and test results — ask a clinician.
The CDC advises 400 mcg of folic acid daily for anyone who could become pregnant. Higher prescription doses (for example 4 mg) are used for people with a previous neural tube defect–affected pregnancy and should only be taken on a doctor's advice. Doses vary by product and person; this is not personal medical advice.
The CDC advises starting at least one month before pregnancy and continuing through early pregnancy, because the neural tube closes in the first weeks.
Usually well tolerated at recommended doses; high doses may cause nausea or stomach upset.
Check your prenatal vitamin — it may already contain the recommended amount. Do not take high doses unless prescribed.
Evidence level (our editorial summary, not a formal grading): Established.
Pregnancy & breastfeeding: Recommended by health authorities before and during pregnancy; many prenatal vitamins already contain it.
Medication interactions: Some anti-seizure medicines and methotrexate interact with folate; ask your doctor. High doses can hide the signs of vitamin B12 deficiency.
Talk to a healthcare professional before use if you are pregnant, breastfeeding, planning pregnancy, have a medical condition, take any medicine, or are scheduled for surgery. Dietary supplements are not approved by the FDA for safety or effectiveness before they are sold, and quality varies between products.
Reliable sources to check: NIH Office of Dietary Supplements fact sheets · NCCIH Herbs at a Glance · MedlinePlus Herbs & Supplements · FDA — Dietary Supplements
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