Essential for T4 to T3 conversion — reduces thyroid antibodies
Selenium is the most important mineral for thyroid health. The thyroid gland has the highest selenium concentration of any organ in the body, and selenium-dependent enzymes are required to convert the inactive thyroid hormone T4 into the active form T3 that cells can use. Selenium also reduces thyroid peroxidase antibodies (TPO antibodies) in Hashimoto's thyroiditis by 50–65% in clinical trials — one of the most dramatic natural effects on autoimmune thyroid disease.
Women with hypothyroidism, Hashimoto's thyroiditis, or those trying to conceive (thyroid health critically affects fertility and pregnancy outcomes).
100–200 mcg selenium daily. This is a narrow therapeutic window — do not exceed 400 mcg daily.
TPO antibody reduction is typically seen within 3–6 months of consistent supplementation.
Safe at recommended doses. Selenosis (toxicity) at doses above 400 mcg daily: hair loss, nail changes, fatigue.
Do not exceed 400 mcg selenium daily from all sources combined. If you eat Brazil nuts regularly, account for that selenium. Get thyroid levels monitored regularly.
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